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Series GSE135378 Query DataSets for GSE135378
Status Public on Jun 30, 2021
Title RNA-seq of DNMT1 inhibitor treated AML cell lines
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Genome wide demethylation by DNMT1 inhibitors GSK3685032 results in up-regulation of epigenetically-silenced genes.
 
Overall design Differential expression was perfomed for each cell line following DNMT1 inhibitor or vehicle treatment across 6 point dose titration and 6 day timecourse. Differentially epressed gene lists were compared across the dose and timecourse.
Web link https://0-doi-org.brum.beds.ac.uk/10.1038/s43018-021-00249-x
 
Contributor(s) Pappalardi MB, McCabe MT, Kellner WA, Keenan K
Citation(s) 34790902
Submission date Aug 05, 2019
Last update date Nov 30, 2021
Contact name Shawn W Foley
E-mail(s) shawn.w.foley@gsk.com
Organization name GlaxoSmithKline
Department Oncology
Street address 1250 S. Collegeville Rd
City Collegeville
State/province PA
ZIP/Postal code 19426
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (156)
GSM4007051 MV411.0nM.DMSO.d1.n1 [S1-01]
GSM4007052 MV411.400nM.GSK032.d1.n1 [S1-02]
GSM4007053 MV411.400nM.DAC.d1.n1 [S1-03]
This SubSeries is part of SuperSeries:
GSE135207 Expression profiling and methylation analysis of DNMT1 inhibitor treated AML cell lines
Relations
BioProject PRJNA558691
SRA SRP217480

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135378_DNMT1_AML_MV411_lfc_table.txt.gz 5.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_NOMO1_lfc_table.txt.gz 4.8 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_THP1_lfc_table.txt.gz 5.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_MV411_table.txt.gz 9.2 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_NOMO1_table.txt.gz 9.1 Mb (ftp)(http) TXT
GSE135378_DNMT1_AML_fpkm_THP1_table.txt.gz 9.6 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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