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Series GSE135511 Query DataSets for GSE135511
Status Public on Dec 17, 2019
Title Gene expression profiling of multiple sclerosis brain samples
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal/glial loss and microglial activation are associated with meningeal inflammation, including the presence of lymphoid-like structures in the subarachnoid space in a proportion of cases. To investigate the molecular consequences of pro-inflammatory and cytotoxic molecules diffusing from the meninges into the underlying grey matter, we carried out gene expression profiling analysis of the motor cortex from 20 post-mortem multiple sclerosis brains with and without substantial meningeal inflammation and 10 non-neurological controls. Gene expression profiling of grey matter lesions and normal appearing grey matter not only confirmed the substantial pathological cell changes, which were greatest in multiple sclerosis cases with increased meningeal inflammation, but also demonstrated the upregulation of multiple genes/pathways associated with the inflammatory response. In particular, genes involved in tumour necrosis factor (TNF) signalling were significantly deregulated in MS cases compared to controls.
 
Overall design Gene expression profiling analysis of the motor cortex from 20 post-mortem multiple sclerosis brains with and without substantial meningeal inflammation and 10 non-neurological controls
 
Contributor(s) Magliozzi R, Durrenberger P, Aricò E, Reynolds R
Citation(s) 31810488
Submission date Aug 07, 2019
Last update date Dec 17, 2019
Contact name Eleonora Arico'
E-mail(s) eleonora.arico@iss.it
Phone 0649902414
Organization name ISS
Lab Istituto Superiore di Sanità
Street address viale Regina Elena 299
City Roma
State/province RM
ZIP/Postal code 00161
Country Italy
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (50)
GSM4013300 Control_Grey_Matter_Tissue_CMS-RZ77
GSM4013301 Control_Grey_Matter_Tissue_CMS-RZ84
GSM4013302 Control_Grey_Matter_Tissue_CMS-RZ90
Relations
BioProject PRJNA559152

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE135511_RAW.tar 3.9 Mb (http)(custom) TAR
GSE135511_non-normalized_data.txt.gz 8.0 Mb (ftp)(http) TXT
Processed data included within Sample table
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