|
| Status |
Public on Oct 27, 2020 |
| Title |
MiRNA-mediated regulation of Bmp2 during pathological calcification |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Renal disease is a major risk factor for cardiovascular disease. BMP2 and its downstream effectors are strong implicators of pathological calcificatoin.
We profiled miRNAs from Klotho mutant mice and from health mice to determine any potential biomarkers for predicting the progression of pathological calcification through targeting of BMP2 and its downstream effectors.
|
| |
|
| Overall design |
1908 miRNA levels measured from 19 mice. Klotho homozygotes (Klkl/kl) exhibited the full phenotype with aortic calcification. Control mice with the wild type (Kl+/+) or heterozygous (Kl+/kl) Klotho genotypes were healthy and indistinguishable.
|
| |
|
| Contributor(s) |
Shah TA, Tang Y, Rogers MB |
| Citation(s) |
32956022 |
| Submission date |
Aug 12, 2019 |
| Last update date |
Oct 29, 2020 |
| Contact name |
Melissa B. Rogers |
| E-mail(s) |
rogersmb@njms.rutgers.edu
|
| Phone |
9739722984
|
| Organization name |
Rutgers NJMS
|
| Department |
Biochem. & Molec. Biology
|
| Lab |
MSB E627
|
| Street address |
185 south orange ave.
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
|
| Samples (19)
|
|
| Relations |
| BioProject |
PRJNA559924 |
Less...
More...