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| Status |
Public on Aug 20, 2019 |
| Title |
A NeuroD1 AAV-Based Gene Therapy For Functional Brain Repair After Ischemic Injury Through In Vivo Astrocyte-To-Neuron Conversion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
NeuroD1-mediated in situ astrocyte-to-neuron conversion can regenerate a large number of functional new neurons after ischemic injury. RNA-sequencing was conducted to confirm neuronal recovery after cell conversion at the mRNA level.
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| Overall design |
Cortical tissues of healthy mice (n = 3), ischemic mice at 17 dpi with control or NeuroD1 virus (n = 2 for each) were collected. mRNA samples were extracted and sequenced.
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| Contributor(s) |
Ma N, Chen Y, Chen G |
| Citation(s) |
31551137 |
| Submission date |
Aug 19, 2019 |
| Last update date |
Nov 25, 2019 |
| Contact name |
Gong Chen |
| Organization name |
Penn State University
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| Street address |
Old Main
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| City |
University Park |
| State/province |
PA |
| ZIP/Postal code |
16802 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA560878 |
| SRA |
SRP218802 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE135981_geo_counts.txt.gz |
312.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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