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Series GSE13600 Query DataSets for GSE13600
Status Public on Jan 28, 2009
Title Use of spermatozoal total RNA profiles to study gene-environment interactions in human germ cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, mRNA profiles from sperm in ejaculates of cigarette smokers (N=4) were compared with non-smokers (N=4). Smoking behaviour was verified by assessing cotinine levels in seminal plasma. Gene-expression analysis was subsequently performed using microarray technology (Agilent human 4x44k) to investigate the use of gene-expression profiling as biomarker of gene-environment interactions in human testis
 
Overall design The study investigated differential gene expression in spermatozoal RNA from 4 smokers as compared to 4 non-smokers. Two conditions: smoking or non-smoking. One individual per array, hybridized against a common reference sample.
 
Contributor(s) Linschooten JO, van Schooten FJ, Baumgartner A, Cemeli E, van Delft J, Anderson D, Godschalk RW
Citation(s) 19409198
Submission date Nov 13, 2008
Last update date Jan 23, 2019
Contact name Joost Linschooten
E-mail(s) Joost.Linschooten@GRAT.unimaas.nl
Phone +31 (0)43 388 1088
URL http://www.grat.nl
Organization name Maastricht University
Department Health Risk Analysis & Toxicology
Street address Universiteitssingel 50
City Maastricht
ZIP/Postal code PO Box 616, 6200 MD
Country Netherlands
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (8)
GSM342311 Smoker 1
GSM342312 Smoker 2
GSM342313 Smoker 3
Relations
BioProject PRJNA110217

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE13600_RAW.tar 67.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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