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Status |
Public on Aug 20, 2019 |
Title |
The effect of attenuated Salmonella typhimurium on the tumor epithelium in mouse colorectal cancer model |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Bacterial cancer therapy (BCT) shows great promise for treatment of solid tumors, yet basic mechanisms of bacterial-induced tumor suppression remain undefined. We aimed to better understand the tumor epithelium-targeted mechanisms of BCT by using mouse models of intestinal tumorigenesis to assess the effectiveness and mechanisms of treatment with aromatase A-deficient Salmonella typhimurium (STm) delivered by oral gavage.
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Overall design |
RNAseq using normal colon tissue or colon tumor induced by AOM/DSS, treated or non-treated with aromatase A-deficient STm delivered by oral gavage
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Contributor(s) |
Oda H, Maslowski KM |
Citation missing |
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Submission date |
Aug 19, 2019 |
Last update date |
Aug 22, 2019 |
Contact name |
Daniel L Kastner |
E-mail(s) |
dan.kastner@nih.gov
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Organization name |
NIH
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Department |
NHGRI
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Street address |
9000 Rockville Pike
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City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (1) |
GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
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Samples (17)
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Relations |
BioProject |
PRJNA560971 |
SRA |
SRP218864 |