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| Status |
Public on Sep 17, 2019 |
| Title |
A comparison of evolutionary changes and constraints on gene regulation between fin and limb development [ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report time-series transcriptome of developing bamboo shark fin buds and mouse forelimb buds, and open chromatin regions of developing mouse forelimb buds. The major contributions of this study are 1) transcriptomic data with an accurate orthology map for a systematic comparison between the two species; 2) high quality chromatin accessibility data for mouse limb development; 3) discovery of mass heterochronic genes between fins and limbs; 4) hourglass-shaped conservation between fins and limbs, providing insights into a general trend of gene regulatory evolution.
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| |
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| Overall design |
ATAC-seq analyses of mouse limb development
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| |
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| Contributor(s) |
Onimaru K, Tatsumi K, Tanegashima C, Kadota M, Nishimura O, Kuraku S |
| Citation(s) |
33560225 |
| Submission date |
Aug 27, 2019 |
| Last update date |
Mar 16, 2021 |
| Contact name |
Koh Onimaru |
| E-mail(s) |
koh.onimaru@gmail.com, koh.onimaru@riken.jp
|
| Phone |
484679398
|
| Organization name |
Center for Biosystems Dynamics Research
|
| Lab |
Laboratory for Bioinformatics Research
|
| Street address |
312 Information Science Building, 2-1 Hirosawa
|
| City |
Wako |
| State/province |
Saitama |
| ZIP/Postal code |
351-0198 |
| Country |
Japan |
| |
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| Platforms (1) |
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| Samples (13)
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| This SubSeries is part of SuperSeries: |
| GSE136445 |
A comparison of evolutionary changes and constraints on gene regulation between fin and limb development |
|
| Relations |
| BioProject |
PRJNA562519 |
| SRA |
SRP219910 |
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