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| Status |
Public on Sep 16, 2019 |
| Title |
Intestinal tumor expression data from Apcmin/+ mice gavaged by feces from healthy controls or colorectal cancer patients |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Colorectal cancer (CRC) is closely related to gut dysbiosis. We investigated the effects of imbalanced gut microbiota on the progression of intestinal adenoma in Apcmin/+ mice model using fecal microbiota transplantation (FMT). Administration of feces from CRC patients increased tumor proliferation and decreased apoptosis in tumor cells. Abnormal expression of genes related to Wnt-protein binding and lipid metabolic process was observed.
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| Overall design |
There were 7 mice in the RNA-seq, which include four in the FMT-AH group (gavage of fecal samples from healthy controls) and three in the FMT-AC group (gavage of fecal samples from patients with CRC).
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| Contributor(s) |
Wang B, Jiang K, Cao H, Li L, Li X |
| Citation(s) |
31594750 |
| Submission date |
Aug 30, 2019 |
| Last update date |
Nov 18, 2019 |
| Contact name |
Lu Li |
| E-mail(s) |
li_lu@tmu.edu.cn
|
| Organization name |
General Hospital, Tianjin Medical University
|
| Department |
Department of Gastroenterology and Hepatology
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| Street address |
154 Anshan Road in Heping District
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| City |
Tianjin |
| ZIP/Postal code |
300052 |
| Country |
China |
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| Platforms (1) |
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| Samples (7)
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| GSM4055172 |
Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep1 [FMT_AH4] |
| GSM4055173 |
Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep2 [FMT_AH5] |
| GSM4055174 |
Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep3 [FMT_AH8] |
| GSM4055175 |
Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep4 [FMT_AH9] |
| GSM4055176 |
Intestinal tumor tissues of mice gavage with feces from CRC patients, biological rep1 [FMT_AC6] |
| GSM4055177 |
Intestinal tumor tissues of mice gavage with feces from CRC patients, biological rep2 [FMT_AC8] |
| GSM4055178 |
Intestinal tumor tissues of mice gavage with feces from CRC patients, biological rep3 [FMT_AC9] |
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| Relations |
| BioProject |
PRJNA563056 |
| SRA |
SRP219923 |
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