 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 07, 2019 |
| Title |
Gene expression study in SF3B1-mutated, NOTCH1-mutated and WT CLL cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Mutations of SF3B1 in CLL induce alternative splicing in multiple transcripts, including DVL2. DVL2 in turn can act as a negative regulator of NOTCH1 signaling. Gene Expression Profile (GEP) was used to investigate the activation of the NOTCH1 pathway in presence of alternatively spliced DVL2.
|
| |
|
| Overall design |
Constitutive gene expression in CLL cells bearing either SF3B1 mutations, NOTCH1 mutation or none of them (WT). Bioinformatic analyses were performed by GenespringGX
|
| |
|
| Contributor(s) |
Pozzo F, Bomben R, Gattei V |
| Citation(s) |
33121237 |
| Submission date |
Sep 06, 2019 |
| Last update date |
Jan 07, 2022 |
| Contact name |
Federico Pozzo |
| E-mail(s) |
federico.pozzo@cro.it
|
| Phone |
+390434659719
|
| Organization name |
Centro di Riferimento Oncologico (CRO) di Aviano IRCCS
|
| Department |
Department of Translational Research
|
| Lab |
Clinical and Experimental Onco Hematology Unit
|
| Street address |
via Franco Gallini 2
|
| City |
Aviano |
| State/province |
PN |
| ZIP/Postal code |
33081 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (28)
|
| GSM4065843 |
CLL cells, 1146_WT |
| GSM4065844 |
CLL cells, 1558_WT |
| GSM4065845 |
CLL cells, 2226_WT |
| GSM4065846 |
CLL cells, 2298_SF3B1 |
| GSM4065847 |
CLL cells, 2546_SF3B1 |
| GSM4065848 |
CLL cells, B1958_SF3B1 |
| GSM4065849 |
CLL cells, B2052_NOTCH |
| GSM4065850 |
CLL cells, B2410_NOTCH |
| GSM4065851 |
CLL cells, B2496_NOTCH |
| GSM4065852 |
CLL cells, B2501_SF3B1 |
| GSM4065853 |
CLL cells, 1028_WT |
| GSM4065854 |
CLL cells, 1110_WT |
| GSM4065855 |
CLL cells, 1999_WT |
| GSM4065856 |
CLL cells, 811_WT |
| GSM4065857 |
CLL cells, 1226_WT |
| GSM4065858 |
CLL cells, 2147_WT |
| GSM4065859 |
CLL cells, 524_WT |
| GSM4065860 |
CLL cells, 338B_WT |
| GSM4065861 |
CLL cells, 603_WT |
| GSM4065862 |
CLL cells, 995_WT |
| GSM4065863 |
CLL cells, 1210_SF3B1 |
| GSM4065864 |
CLL cells, 1620_SF3B1 |
| GSM4065865 |
CLL cells, 1995_SF3B1 |
| GSM4065866 |
CLL cells, 2276_NOTCH |
| GSM4065867 |
CLL cells, 2360_SF3B1 |
|
| Relations |
| BioProject |
PRJNA564296 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE137024_RAW.tar |
207.9 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...