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| Status |
Public on Nov 22, 2008 |
| Title |
The effects of dietary curcumin on colonic gene expression in TNBS-induced colitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Curcumin is a potent anti-inflammatory compound capable of preventing chemically induced colitis in mice.
We used microarray analysis to detail the global programme of colonic gene expression in BALB/c mice fed standard or 2% curcumin-supplemented diet and treated with control or TNBS (trnitrobenzene-sulfonic acid, 2 mg/mouse) enema.
Keywords: Diet and disease effect.
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| Overall design |
6-8 week old BALB/c mice were treated with respecive diet two days prior to enema administration (day 0) and sacrificed on day 7. Whole colon was dissected from mice and their wild-type littermates and total RNA isolated for microarray analysis using Affymetrix murine MOE430 mouse array set. RNA was pooled from 3 mice in each dietary/treatment group.
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| |
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| Contributor(s) |
Kiela PR |
| Citation(s) |
18200517 |
| Submission date |
Nov 21, 2008 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Pawel R. Kiela |
| E-mail(s) |
pkiela@peds.arizona.edu
|
| Phone |
520-626-9687
|
| Organization name |
University of Arizona
|
| Department |
Pediatrics
|
| Lab |
Gastroenterology and Nutrition
|
| Street address |
1501 N. Campbell Ave.
|
| City |
Tucson |
| State/province |
AZ |
| ZIP/Postal code |
85724 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL340 |
[MOE430B] Affymetrix Mouse Expression 430B Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA109435 |
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