|
| Status |
Public on Apr 09, 2021 |
| Title |
Promoter-wide profiling of DNA methylation in human neuroblastoma cells cultured with mood stabilizers. |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD.
|
| |
|
| Overall design |
Promoter-wide profiling of DNA methylation in human neuroblastoma cells cultured with mood stabilizers.
In total 11 samples; 5 reference files (different conditions) and 6 drug treated files (different conditions).
|
| |
|
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 11, 2019 |
| Last update date |
Apr 11, 2021 |
| Contact name |
Junko Ueda |
| E-mail(s) |
junko.hayashi.aa@riken.jp
|
| Organization name |
RIKEN
|
| Department |
Center for Brain Science
|
| Lab |
Laboratory for Molecular Dynamics of Mental Disorders
|
| Street address |
2-1 Hirosawa
|
| City |
Wako |
| State/province |
Saitama |
| ZIP/Postal code |
351-0198 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL5082 |
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array |
|
| Samples (11)
|
| GSM4073931 |
Cultured SK-N-SH cells, Valproate (0.3 mM)_SH-1 |
| GSM4073932 |
Cultured SK-N-SH cells, Valproate (0.6 mM)_SH-2 |
| GSM4073933 |
Cultured SK-N-SH cells, Lithium (0.6 mM)_SH-3 |
| GSM4073934 |
Cultured SK-N-SH cells, Lithium (1.2 mM)_SH-4 |
| GSM4073935 |
Cultured SK-N-SH cells, Carbamazepine (0.05 mM)_SH-5 |
| GSM4073936 |
Cultured SK-N-SH cells, Carbamazepine (0.1 mM)_SH-6 |
| GSM4073937 |
Cultured SK-N-SH cells, control_SH-8 |
| GSM4073938 |
Cultured SK-N-SH cells, control_SH-14 |
| GSM4073939 |
Cultured SK-N-SH cells, DMSO (1ul/ ml)_SH-17 |
| GSM4073940 |
Cultured SK-N-SH cells, DMSO (0.5ul/ ml)_SH-18 |
| GSM4073941 |
Cultured SK-N-SH cells, control_SH-20 |
|
| This SubSeries is part of SuperSeries: |
| GSE137921 |
Promoter-wide profiling of DNA methylation changes in bipolar disorder |
|
| Relations |
| BioProject |
PRJNA564943 |
Less...
More...