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| Status |
Public on Jan 01, 2009 |
| Title |
Microarray analysis of the development of proteinuria in the Dahl salt-sensitive rat |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
To get more insight in cause and consequences of proteinuria, we studied glomerular gene expression patterns before and after the onset of increased urinary albumin excretion in a proteinuric rat strain.
Spontaneously proteinuric Dahl salt-sensitive rats (Dahl SS) were compared to non-proteinuric, spontaneously hypertensive rats (SHR). In Dahl SS, UAE significantly increased starting from week 5 of age. Glomerular RNA profiles of 4- and 6 week-old rats were studied by Affymetrix microarrays.
Keywords: Time course analysis
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| Overall design |
RNA was extracted from isolated glomeruli of 4- and 6 week-old rats from both strains. At each time point, two rats were used for each strain.
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| Contributor(s) |
Koop K |
| Citation(s) |
30350425 |
| Submission date |
Dec 03, 2008 |
| Last update date |
Oct 29, 2018 |
| Contact name |
klaas koop |
| Organization name |
Leiden University Medical Center
|
| Department |
Pathology
|
| Street address |
Albinusdreef 2
|
| City |
Leiden |
| ZIP/Postal code |
2300 RC |
| Country |
Netherlands |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA110581 |
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