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| Status |
Public on Aug 01, 2009 |
| Title |
Expression profiling of Bos taurus lymph nodes upon infection with Ovine Herpesvirus 2 |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by array
|
| Summary |
We hypothesized that the relative abundances of host cell transcripts in lymph nodes of animals with malignant catarrhal fever (MCF), compared to healthy controls, may be used to identify pathways that may help to explain the pathogenesis of MCF. Therefore, an abundance of host cell gene expression patterns in lymph nodes of animals with MCF and healthy controls were analyzed by microarray. Indeed, a vast number of genes related to inflammatory processes, lymphocyte activation, cell proliferation and apoptosis were detected at different abundances. However, the IL-2 transcript was eminent among the transcripts, which were, compared to healthy controls, less abundant in animals with MCF. Compared to healthy cattle, bovines with MCF appear to mimic an IL-2 knockout phenotype that has been described in mice. This supports the hypothesis that immunopathogenic events are linked to the pathogenesis of MCF. IL-2-deficiency may play an important role in the process.
Keywords: disease state analysis
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| |
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| Overall design |
Comparison of lymph node samples from 3 infected animals with lymph node samples from 6 uninfected animals.
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| Contributor(s) |
Meier-Trummer CS, Rehrauer H, Patrignani A, Wagner U, Ackermann M |
| Citation(s) |
19603070 |
| Submission date |
Dec 05, 2008 |
| Last update date |
Dec 17, 2012 |
| Contact name |
Hubert Rehrauer |
| E-mail(s) |
Hubert.Rehrauer@fgcz.ethz.ch
|
| Organization name |
ETH Zurich / University of Zurich
|
| Department |
FGCZ
|
| Street address |
Winterthurerstr. 190
|
| City |
Zurich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL2112 |
[Bovine] Affymetrix Bovine Genome Array |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE13854 |
Expression profiling of the host and the Ovine Herpesvirus 2 pathogen during malignant catarrhal fever of cattle |
|
| Relations |
| BioProject |
PRJNA114591 |
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