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Status |
Public on Oct 31, 2020 |
Title |
RNA-seq timecourse of p53 activation with Nutlin-3a in IMR90 cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
To investigate the dynamics of the p53 response, we treated IMR90 cells with Nutlin-3a, a small molecule that inhibits the interaction between p53 and its inhibitor Mdm2, for 6, 9, or 12 hours.
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Overall design |
RNA-seq in IMR90 cells treated with Nutlin-3a (inhibitor to Mdm2-p53 interaction) for 6, 9, or 12 hours or treated with a DMSO control.
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Contributor(s) |
Alexander KA, Berger SL |
Citation missing |
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NIH grant(s) |
Grant ID |
Grant title |
Affiliation |
Name |
F32 CA221010 |
Modulation of wild type and mutant p53 by HMGA1 |
UNIVERSITY OF PENNSYLVANIA |
Katherine Ann Alexander |
R01 CA078831 |
Epigenetic regulation by tumor suppressor p53 |
UNIVERSITY OF PENNSYLVANIA |
SHELLEY L BERGER |
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Submission date |
Oct 17, 2019 |
Last update date |
Oct 31, 2020 |
Contact name |
Katherine A Alexander |
E-mail(s) |
kaalexa@pennmedicine.upenn.edu
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Organization name |
University of Pennsylvania
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Street address |
Smilow Center for Translational Research
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City |
Philadelphia |
State/province |
Pennsylvania |
ZIP/Postal code |
19104 |
Country |
USA |
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Platforms (1) |
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Samples (8)
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Relations |
BioProject |
PRJNA578044 |
SRA |
SRP226017 |