|
| Status |
Public on Apr 30, 2020 |
| Title |
Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [CUT&RUN] |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for function restoration. Tex cells elicited by chronic infection contain a CXCR5+Tim3– subset that has stem cell-like self-renewing capacity and expresses an elevated level of Tcf1 (termed Tex-stem), and Tex-stem cells depend on Tcf1 for generation and persistence. We show that ectopic Tcf1 expression profoundly affected the transcriptome and chromatin accessibility of Tex cells.
|
| |
|
| Overall design |
Genome-wide mapping of Tcf1 occupancy in f stem cell-like exhauseted CD8+ T cells with ectopic Tcf1 expression.
|
| |
|
| Contributor(s) |
Qiang S, Sheng'en H, Chongzhi Z, Hai-Hui X |
| Citation(s) |
32341523 |
| Submission date |
Oct 17, 2019 |
| Last update date |
Apr 30, 2020 |
| Contact name |
Haihui Xue |
| E-mail(s) |
haihui.xue@hmh-cdi.org
|
| Organization name |
Hackensack University Medial Center
|
| Department |
Center for Discovery and Innovation
|
| Lab |
Xue lab
|
| Street address |
123 Metro Boulevard, Bldg. 123, Rm. 5527
|
| City |
Nutley |
| State/province |
NJ |
| ZIP/Postal code |
07110 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (2) |
|
| This SubSeries is part of SuperSeries: |
| GSE139058 |
Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features |
|
| Relations |
| BioProject |
PRJNA578160 |
| SRA |
SRP226111 |
