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Status |
Public on Mar 26, 2020 |
Title |
Microarray Analysis of Striatal Tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated Parkinsonian and Dyskinetic (LID) Rats as compared to Parkinsonian Disease (PD) Control Rats |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by array
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Summary |
We compared differential gene expression between Striatal tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated (L-Dopa methyl ester plus benserazide were given at 25 mg/kg and 6.25 mg/kg dose) - Parkinsonian and Dyskinetic Rats (LID Rats) for 8 days as compared to Parkinsonian Disease Control Rats (PD Control Rats). The hypothesis tested in the present study was that whether Inflammation has any role in Chronic Levodopa Induced Dyskinesia in Rats of Parkinson's disease model- as compared to Control Rats with Prakinson's disease by performing differential gene expression and pathway analyses.
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Overall design |
On Day 8 Post Chronic Levodopa treatment, the total RNA was extracted from striatal tissue of Chronic Levodopa (L-DOPA) treated Parkinsonian and Dyskinetic (LID) and Rats with Parkinsonian Disease (PD) Controls.
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Contributor(s) |
DYAVAR SR, Papa SM |
Citation missing |
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Submission date |
Oct 27, 2019 |
Last update date |
Mar 28, 2020 |
Contact name |
SHETTY RAVI DYAVAR |
E-mail(s) |
dyavarsravi@gmail.com
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Phone |
4042735756
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Organization name |
University of Nebraska Medical Center
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Department |
Pharmacy Practice and Science
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Lab |
Antiviral Pharmacology
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Street address |
4040 EMILE ST
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City |
Omaha |
State/province |
NE |
ZIP/Postal code |
68134 |
Country |
USA |
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Platforms (1) |
GPL6101 |
Illumina ratRef-12 v1.0 expression beadchip |
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Samples (12)
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Relations |
BioProject |
PRJNA579835 |