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Series GSE139438 Query DataSets for GSE139438
Status Public on Mar 26, 2020
Title Microarray Analysis of Striatal Tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated Parkinsonian and Dyskinetic (LID) Rats as compared to Parkinsonian Disease (PD) Control Rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary We compared differential gene expression between Striatal tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated (L-Dopa methyl ester plus benserazide were given at 25 mg/kg and 6.25 mg/kg dose) -
Parkinsonian and Dyskinetic Rats (LID Rats) for 8 days as compared to Parkinsonian Disease Control Rats (PD Control Rats). The hypothesis tested in the present study was that whether Inflammation has any role in Chronic Levodopa Induced Dyskinesia in Rats of Parkinson's disease model-
as compared to Control Rats with Prakinson's disease by performing differential gene expression and pathway analyses.
 
Overall design On Day 8 Post Chronic Levodopa treatment, the total RNA was extracted from striatal tissue of Chronic Levodopa (L-DOPA) treated Parkinsonian and Dyskinetic (LID) and Rats with Parkinsonian Disease (PD) Controls.
 
Contributor(s) DYAVAR SR, Papa SM
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Submission date Oct 27, 2019
Last update date Mar 28, 2020
Contact name SHETTY RAVI DYAVAR
E-mail(s) dyavarsravi@gmail.com
Phone 4042735756
Organization name University of Nebraska Medical Center
Department Pharmacy Practice and Science
Lab Antiviral Pharmacology
Street address 4040 EMILE ST
City Omaha
State/province NE
ZIP/Postal code 68134
Country USA
 
Platforms (1)
GPL6101 Illumina ratRef-12 v1.0 expression beadchip
Samples (12)
GSM4141686 PD Control Rat Striatal Microarray 1
GSM4141687 PD Control Rat Striatal Microarray 2
GSM4141688 PD Control Rat Striatal Microarray 3
Relations
BioProject PRJNA579835

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139438_RAW.tar 16.0 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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