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| Status |
Public on Oct 23, 2020 |
| Title |
RNA sequencing results of dipyridamole treatment in SLC29A2-expressing SK-hep1 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We observed an increasing trend of nuclear SLC29A2 expression associated with high histological de-differentiation grades, metastasis and poor patient prognosis by immunohistochemical analysis of HCC tumors. Treatments of dipyridamole to SLC29A2 expressing SK-hep1 cells reduced cell viability and cell migration. To examine the anticancer activities of dipyridamole, transcriptome analysis was performed to detect the modulations of oncogenic SLC29A2 and the downstream signaling pathways.
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| Overall design |
Gene expression profiles of dipyridamole and/or sorafenib treatment in SLC29A2-expressing Sk-hep1 cells were generated by Illumina RNA sequencing and compared to profiles derived from mock control cells.
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| Contributor(s) |
Shen R, Jou Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 30, 2019 |
| Last update date |
Oct 25, 2020 |
| Contact name |
Roger Shen |
| E-mail(s) |
linsivvi@gmail.com
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| Organization name |
Academia Sinica
|
| Street address |
128 Sec. 2, Academia Rd. Nankang
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| City |
Taipei |
| ZIP/Postal code |
11529 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA580370 |
| SRA |
SRP227430 |
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