|
| Status |
Public on Oct 30, 2020 |
| Title |
Cystic Fibrosis Keystone Species |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This project shows that the use of antibiotics targeting gram-positive, anaerobic bacteria can improve patient's health by removing the main nutritional sources of classic pathogens. These antibiotics, traditionally not used in CF therapy, target anaerobes that efficiently degrade mucus providing metabolic products that feed and stimulate the expression of virulence factors in Pseudomonas. They work as keystone groups sustaining the stability of the entire microbial community, and their control drives a decrease in Pseudomonas abundance and virulence.
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| |
|
| Overall design |
9 transcriptomes from longitudinal sampling of the same patient.
|
| |
|
| Contributor(s) |
Silveira C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 05, 2019 |
| Last update date |
Nov 01, 2020 |
| Contact name |
Cynthia Silveira |
| E-mail(s) |
csilveira@sdsu.edu
|
| Organization name |
San Diego State University
|
| Department |
Biology
|
| Street address |
5500 Campanile Dr, North Life Sciences 302
|
| City |
San Diego |
| State/province |
CALIFORNIA |
| ZIP/Postal code |
92182 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA587705 |
| SRA |
SRP228590 |
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