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Series GSE140461 Query DataSets for GSE140461
Status Public on May 28, 2020
Title Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis - PART 1 (Liver Regeneration)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The scope of this project is to study, using state-of-the-art systems biology approaches integrating the changes in metabolomics, lipidomics and transcriptomics, changes in hepatocytes' metabolism occurring in liver regeneration. We focused on altered metabolic pathways including lipogenesis, fatty acid desaturation, and generation of phosphatidylcholine (PC) occurring in the liver following partial hepatectomy (PH) or carbon-tetrachloride (CCl4) injection.
 
Overall design Male C57BL/6J mice were challenged with A) IP injection of 2ul/g body weight of olive oil (OO) or CCl4:olive oil [1:1 (v/v)] mix; Mice were culled 3 days after IP injection. B) Partial Hepatectomy; Mice were culled 3 days after surgery.
 
Contributor(s) Vacca M, Hall Z, Chiarugi D
Citation(s) 32460431
Submission date Nov 15, 2019
Last update date Sep 23, 2020
Contact name Davide Chiarugi
E-mail(s) ims-bioinformatics@medschl.cam.ac.uk
Organization name WT-MRC Institute of Metabolic Science
Department Metabolic Research Laboratories
Street address Box 289, Addenbrooke’s Hospital
City Cambridge
ZIP/Postal code CB2 0QQ
Country United Kingdom
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (16)
GSM4162210 CCL4-04-WT
GSM4162211 CCL4-05-WT
GSM4162212 CCL4-07-WT
This SubSeries is part of SuperSeries:
GSE140463 Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis
Relations
BioProject PRJNA589848
SRA SRP230191

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140461_RAW.tar 57.1 Mb (http)(custom) TAR (of TAB)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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