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| Status |
Public on May 28, 2020 |
| Title |
Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis - PART 2 (Human HCC - "Fatty Liver" background) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The scope of this project is to study, using state-of-the-art systems biology approaches integrating the changes in metabolomics, lipidomics and transcriptomics, changes in hepatocytes' metabolism occurring in human HCC. We focused on altered metabolic pathways including lipogenesis, fatty acid desaturation, and generation of phosphatidylcholine (PC) occurring in HCC vs. paired HCC-free tissue.
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| |
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| Overall design |
HCC samples and paired HCC-free tissues were collected during hepatectomy or transplant.
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| |
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| Contributor(s) |
Hoare M, Allison M, Vacca M, Hall Z, Chiarugi D |
| Citation(s) |
32460431 |
| Submission date |
Nov 15, 2019 |
| Last update date |
Sep 23, 2020 |
| Contact name |
Davide Chiarugi |
| E-mail(s) |
ims-bioinformatics@medschl.cam.ac.uk
|
| Organization name |
WT-MRC Institute of Metabolic Science
|
| Department |
Metabolic Research Laboratories
|
| Street address |
Box 289, Addenbrooke’s Hospital
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 0QQ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE140463 |
Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis |
|
| Relations |
| BioProject |
PRJNA589847 |
| SRA |
SRP230192 |
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