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Series GSE140980 Query DataSets for GSE140980
Status Public on Nov 26, 2019
Title Transcriptomic analysis of ETV6/RUNX1 KO lymphoid cell line generated by CRISPR/Cas9 showed a distinct expression signature and a deregulation of its downstream signaling genes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The gene expression profile of E/R KO clones versus REH cells and controls clones, analysed by total RNA-sequencing, showed a total of 342 genes differentially expressed (q<0.05), 182 upregulated and 160 downregulated. The heatmap of the top50 of the most deregulated genes according to fold change (FC) values showed a distinct expression signature of E/R KO clones as compared with REH cells and control clones
 
Overall design Purpose: Analyse the gene expression profile of ETV6/RUNX1 KO clones versus REH cells and controls clones by total RNA-sequencing to elucidate the functional effects of fusion gene abrogation in ALL cells.
 
Contributor(s) Hernández Rivas JM
Citation(s) 31952221
Submission date Nov 25, 2019
Last update date Feb 25, 2020
Contact name Adrian Montano
E-mail(s) adrianmo18@gmail.com
Organization name Cancer research center
Street address Campus Miguel de Unamuno SN
City Salamanca
ZIP/Postal code 37007
Country Spain
 
Platforms (1)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (6)
GSM4191856 REH-L12-CUL-RNA
GSM4191857 C1-L12-CUL-RNA
GSM4191858 C3-L12-CUL-RNA
Relations
BioProject PRJNA591607
SRA SRP233213

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140980_counts.norm.csv.gz 576.8 Kb (ftp)(http) CSV
GSE140980_dge.Fusion_KO-vs-Control.q005.xlsx 21.5 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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