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| Status |
Public on Mar 01, 2020 |
| Title |
Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice.
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| Overall design |
Using scRNAseq to compare the gene expression profiles of smooth muscle cells beteewn ApoE mice and SMC specific TGFbR2 KO Apoe mice fed with high fat diet
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| Contributor(s) |
Simons M, Chen P |
| Citation(s) |
32243809 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL135582 |
Endothelial-to-mesenchyma transition and atherosclerosis |
YALE UNIVERSITY |
Michael Simons |
|
| Submission date |
Nov 26, 2019 |
| Last update date |
Apr 08, 2020 |
| Contact name |
Michael Simons |
| E-mail(s) |
michael.simons@yale.edu
|
| Organization name |
Yale University
|
| Department |
Department: Internal Medicine Cardiology
|
| Lab |
Yale Cardiovascular Research Center
|
| Street address |
3oo George St, Suite 773
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
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| Platforms (1) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE141032 |
Smooth muscle cell reprogramming in aortic aneurysms |
|
| Relations |
| BioProject |
PRJNA591808 |
| SRA |
SRP233287 |
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