NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE141349 Query DataSets for GSE141349
Status Public on Apr 21, 2021
Title Role of splicing factor SRSF1 during the late stages of T cell maturation in the thymus
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Other
Summary In thymus, the post-selection single positive thymocytes undergo further intrathymic maturation including down-regulation of CD69 and CD24, up-regulation of Qa-2, through which single positive thymocytes became equipped with emigration competency, then emigrate to periphery. Here we find that RNA binding protein Srsf1 is essential for the final maturation and survival of thymocytes.
 
Overall design 5 RNA-Seq samples:3 WT replicates and 2 SRSF1 KO replicates; 4 CLIP-seq samples: 2 SRSF1 CLIP-seq replicates, 2 IgG CLIP-seq replicates
 
Contributor(s) Yu S, Qi Z
Citation(s) 33863728, 35154164
Submission date Dec 03, 2019
Last update date Feb 18, 2022
Contact name Shuyang Yu
E-mail(s) ysy@cau.edu.cn
Organization name China Agricultural University
Department College of Biological Sciences
Street address 2 Yuanmingyuan West Road
City Beijing
ZIP/Postal code 100193
Country China
 
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (9)
GSM4201636 RNA-seq WT_rep1
GSM4201637 RNA-seq WT_rep2
GSM4201638 RNA-seq WT_rep3
Relations
BioProject PRJNA593200
SRA SRP234535

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141349_RAW.tar 3.2 Gb (http)(custom) TAR (of BW)
GSE141349_count.txt.gz 393.9 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap