|
Status |
Public on Apr 21, 2021 |
Title |
Role of splicing factor SRSF1 during the late stages of T cell maturation in the thymus |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Other
|
Summary |
In thymus, the post-selection single positive thymocytes undergo further intrathymic maturation including down-regulation of CD69 and CD24, up-regulation of Qa-2, through which single positive thymocytes became equipped with emigration competency, then emigrate to periphery. Here we find that RNA binding protein Srsf1 is essential for the final maturation and survival of thymocytes.
|
|
|
Overall design |
5 RNA-Seq samples:3 WT replicates and 2 SRSF1 KO replicates; 4 CLIP-seq samples: 2 SRSF1 CLIP-seq replicates, 2 IgG CLIP-seq replicates
|
|
|
Contributor(s) |
Yu S, Qi Z |
Citation(s) |
33863728, 35154164 |
Submission date |
Dec 03, 2019 |
Last update date |
Feb 18, 2022 |
Contact name |
Shuyang Yu |
E-mail(s) |
ysy@cau.edu.cn
|
Organization name |
China Agricultural University
|
Department |
College of Biological Sciences
|
Street address |
2 Yuanmingyuan West Road
|
City |
Beijing |
ZIP/Postal code |
100193 |
Country |
China |
|
|
Platforms (2) |
|
Samples (9)
|
|
Relations |
BioProject |
PRJNA593200 |
SRA |
SRP234535 |