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| Status |
Public on Dec 06, 2019 |
| Title |
Microarray comparing CMV-specific CD8+ T cells from liver sinusoid and peripheral blood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The liver is an immunologically unique organ in terms of the regulation of immuno-tolerance and immune responses. Recently, non-recirculating tissue-resident memory T (TRM) cells expressing CD69 were found in various peripheral organs. In humans, a large population of CD69+CD8+ memory T cells residing in liver sinusoids shows reduced cytotoxicity. However, the trascriptional characteristics of human liver CD8+ T cells are still unknown. Therefore, we performed a microarray analysis to screen the gene expression profile in liver sinusoidal CD8+ T cells using CMV-specific CD8+ T cells from human peripheral blood and liver sinusoid.
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| Overall design |
We performed microarray analysis after sorting HLA-A*0201-CMVpp65495 pentamer+CD8+ T cells from paired LSMCs and PBMCs.
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| Contributor(s) |
Han JW, Kim JH, Shin E |
| Citation(s) |
31987989 |
| Submission date |
Dec 05, 2019 |
| Last update date |
Mar 06, 2020 |
| Contact name |
Ji Won Han |
| E-mail(s) |
tmznjf@kaist.ac.kr
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| Phone |
+82-10-2783-9905
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| Organization name |
KAIST
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| Street address |
Daehak-ro 291
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| City |
Yuseong-gu |
| State/province |
Daejeon |
| ZIP/Postal code |
34141 |
| Country |
South Korea |
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| Platforms (1) |
| GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA593735 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE141508_RAW.tar |
17.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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