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Series GSE141512 Query DataSets for GSE141512
Status Public on Dec 06, 2019
Title Expression data for patients with myocardial infarction (MI) vs healthy patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known, that the central component of CAD pathogenesis is a chronic vascular inflammation. However, the mechanisms underlying the changes that occur in T, B and NK-lymphocytes, monocytes and other immune cells during CAD and MI are still poorly understood. One of those pathogenic mechanisms might be the dysregulation of intracellular signaling pathways in the immune cells.
In the present study we performed a transcriptome profiling in peripheral blood mononuclear cells of MI patients and healthy individuals. The machine learning algorithm was then used to search for MI-associated signatures, that could reflect the dysregulation of intracellular signaling pathways and be assisted in MI diagnosis and/or prognosis.
ADAP2, KLRC1, MIR21, PDGFD and CD14 genes were identified as the most important signatures for the classification model with L1-norm penalty function. The classifier output quality was equal to 0.911 by Receiver Operating Characteristic metric on test data. These results were validated on two independent open GEO datasets.
 
Overall design 6 patients with myocardial infarction (MI) were analyzed vs 6 healty patients
 
Contributor(s) Osmak G, Baulina N, Koshkin P, Favorova O
Citation(s) 32517814
Submission date Dec 05, 2019
Last update date Jun 16, 2020
Contact name German Osmak
E-mail(s) german.osmak@gmail.com
Organization name National Medical Research Center for Cardiology
Street address 3-ya Cherepkovskaya
City Moscow
ZIP/Postal code 121552
Country Russia
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (12)
GSM4205353 Patient with MI 1
GSM4205354 Patient with MI 2
GSM4205355 Patient with MI 3
Relations
BioProject PRJNA593748

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Supplementary file Size Download File type/resource
GSE141512_RAW.tar 284.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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