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| Status |
Public on Dec 10, 2019 |
| Title |
Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1 |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
We demonstrated that, four weeks after the pulmonary artery banding (PAB) operation, rats could be divided into two groups: an F+ group in which the fibrotic area occupied more than 6.5% of the whole area of the heart tissues, and an F- group in which the fibrotic area occupied less than 6.5% of this area.
We used microarrays to elucidate the fibrosis initiating master factor using heart samples obtained from PAB or sham-operated rats.
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| Overall design |
Frozen rat right ventricles in the Sham, F- (no fibrosis), and F+ (fibrosis) groups were used (n=3 each). Then microarray analysis was performed.
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| Contributor(s) |
Uesugi K, Minamisawa S |
| Citation(s) |
32315372 |
| Submission date |
Dec 09, 2019 |
| Last update date |
May 14, 2020 |
| Contact name |
Toru Akaike |
| E-mail(s) |
takaike@jikei.ac.jp
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| Organization name |
The Jikei University
|
| Department |
Cell Physiology
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| Street address |
3-25-8 Nishi-Shimbashi, Minato-ku
|
| City |
Tokyo |
| ZIP/Postal code |
1058461 |
| Country |
Japan |
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| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA594298 |
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