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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 17, 2019 |
| Title |
ATF2 and ATF7 mediation of intestinal repair in murine colitis model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
AP1 transcription factor family members: activating transcription factor 2 (ATF2) and activating transcription factor 7 (ATF7) have highly redundant functions due to homology and hence overlapping DNA-binding sites. The role of these transcription factors in intestinal epithelial homeostasis and repair has not been critically examined. Here, by using an intestine-specific deletion of ATF2 combined with body wide deletion of ATF7 in mice we assess the role of these proteins during intestinal homeostasis and repair after inflammation.
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| Overall design |
12h treatment of WT and ATF2 KO/ATF7 fl/fl colon organoids with 50ng/ml of recombinant mouse TNF-alpha
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| Contributor(s) |
Meijer BJ, Muncan V |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 16, 2019 |
| Last update date |
Dec 21, 2019 |
| Contact name |
Sander Meisner |
| E-mail(s) |
s.meisner@amsterdamumc.nl
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| Phone |
0031205668158
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| Organization name |
AMC
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| Department |
Tytgat institute
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| Lab |
DIGEST
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| Street address |
Meibergdreef 69-71
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| City |
Amsterdam |
| State/province |
NH |
| ZIP/Postal code |
1105BK |
| Country |
Netherlands |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (16)
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| GSM4218568 |
Colon organoids, WT 4 |
| GSM4218569 |
Colon organoids, WT 1 + TNFa |
| GSM4218570 |
Colon organoids, WT 2 + TNFa |
| GSM4218571 |
Colon organoids, WT 3 + TNFa |
| GSM4218572 |
Colon organoids, WT 4 + TNFa |
| GSM4218573 |
Colon organoids, ATF2/7 fl 1 + TNFa |
| GSM4218574 |
Colon organoids, ATF2/7 fl 2 + TNFa |
| GSM4218575 |
Colon organoids, ATF2/7 fl 3 + TNFa |
| GSM4218576 |
Colon organoids, ATF2/7 fl 4 + TNFa |
| GSM4218577 |
Colon organoids, ATF2/7 fl 1 |
| GSM4218578 |
Colon organoids, ATF2/7 fl 2 |
| GSM4218579 |
Colon organoids, ATF2/7 fl 3 |
| GSM4218580 |
Colon organoids, ATF2/7 fl 4 |
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| Relations |
| BioProject |
PRJNA595848 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE142065_RAW.tar |
18.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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