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Status |
Public on Dec 20, 2019 |
Title |
Gene expression profiling in B220+ from normal spleen, VavPBcl2/vector and VavPBcl2/Myc lymphomas |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Follicular lymphoma (FL) is the second most common forms of B cell lymphoma that result from the expansion of germinal center (GC) B cells. Here, we aimed to find differential expression of genes between noemal spleen, indoent FL (VavPBcl2/vector) and transformed and aggressive FL (VavPBcl2/MYC) in our mouse model.
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Overall design |
Using RNAseq we profiled murine purified B220+ cells from normal spleen (n=4), lymphomas transduced with empty vector (n=8) or Myc (n=8)
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Contributor(s) |
Parsa S, Ortega-Molina A, Socci N, Reznik E, Wendel H |
Citation(s) |
33569544 |
Submission date |
Dec 19, 2019 |
Last update date |
Feb 16, 2021 |
Contact name |
Sara Parsa |
E-mail(s) |
parsas@mskcc.org
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Phone |
9493004413
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Organization name |
Memorial Sloan-Kettering Cancer Center
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Department |
Cancer Biology and Genetics
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Lab |
Wendel Lab
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Street address |
408 E 69th st, Z-1335
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City |
New York |
State/province |
NY |
ZIP/Postal code |
10021 |
Country |
USA |
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Platforms (1) |
GPL18635 |
Ion Torrent Proton (Mus musculus) |
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Samples (20)
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This SubSeries is part of SuperSeries: |
GSE142336 |
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. |
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Relations |
BioProject |
PRJNA596662 |
SRA |
SRP238215 |