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| Status |
Public on May 04, 2020 |
| Title |
Hyperuricemia Predisposes to the Onset of Diabetes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To further examine the mechanisms of urate in islet β-cell death, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish primacy of streptozotocin (STZ) vs. urate. Islets were isolated from Uox-KO and WT mice with and without multiple low-dose STZ. Differentially expressed genes (DEGs) in islets of the hyperuricemic and/or diabetic mice in comparison to their respective controls represented specific Gene Ontology (GO) pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional meanings.
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| Overall design |
Diabetic mice models were intraperitoneally injected with multiple low-dose STZ at a dose of 40 mg/kg body weight daily, for 5 consecutive days. Hyperuricemic mice and their counterparts were also included.Four groups (KO, WT, STZ-KO and STZ-WT) were designed with three replications in each.
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| Contributor(s) |
Lu J, Li C |
| Citation(s) |
32312870 |
| Submission date |
Dec 20, 2019 |
| Last update date |
Aug 03, 2020 |
| Contact name |
Jie Lu |
| E-mail(s) |
13127006046@163.com
|
| Phone |
13127006046
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| Organization name |
Qingdao University
|
| Street address |
16 Jiangsu Rd
|
| City |
Qingdao |
| ZIP/Postal code |
266003 |
| Country |
China |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA596990 |
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