NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE142627 Query DataSets for GSE142627
Status Public on Dec 27, 2019
Title Methylation Profiling of Medulloblastoma in a Clinical Setting Permits Sub-Classification and Reveals New Outcome Predictions
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary In this study, we report the first examination of Medulloblastoma (MB) methylation patterns in Arab world, using an extensive primary tumor cohort in tertiray care center. We assessed DNA methylation patterns to sub-classify clinical MB cases and their amenability to clinical applications from archival biopsy material (FPPE). We herein establish methylation events as clinically useful biomarkers and demonstrate how their incorporation into current risk-stratification schemes could significantly improve the accuracy of survival predictions in clinical setting. This holds potential for future precision therapeutic approaches aimed at improving the outcomes of afflicted MB patients.
 
Overall design experimental retrospective
 
Contributor(s) Malak A, Matija S
Citation(s) 32265819
Submission date Dec 26, 2019
Last update date Mar 24, 2021
Contact name Malak Abedalthagafi
E-mail(s) malthagafi@kacst.edu.sa
Organization name King Abdulaziz City for Science and Technology
Department Genomics Research
Lab Saudi Human Genome Lab
Street address King Abdullah Rd
City Riyadh
State/province Ar Raid
ZIP/Postal code 12354
Country Saudi Arabia
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (40)
GSM4233108 genomic DNA from FFPE tumor section #42
GSM4233109 genomic DNA from FFPE tumor section #29
GSM4233110 genomic DNA from FFPE tumor section #14
Relations
BioProject PRJNA597772

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE142627_RAW.tar 720.8 Mb (http)(custom) TAR (of IDAT)
GSE142627_processed_data.txt.gz 171.5 Mb (ftp)(http) TXT
Processed data are available on Series record
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap