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Series GSE142635 Query DataSets for GSE142635
Status Public on Aug 13, 2020
Title Transcriptome of Immortalized Mouse Corneal Endothelial Cells with SLC4A11 deficiency
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mutations in the solute-linked carrier family 4 member 11 (SLC4A11) gene are associated with several corneal endothelial dystrophies, in all of which visually significant cornea edema may require corneal transplantation. To elucidate the pathogenesis of SLC4A11 associated corneal endothelial dystrophies, we analyzed the transcriptome of immortalized mouse corneal endothelial cells (Slc4a11-/- MCEnC) and Slc4a11+/+ MCEnC as controls.
Overall design Slc4a11-/- MCEnC P7 (n=3) vs Slc4a11+/+ MCEnC P6 (n=3); Slc4a11-/- MCEnC P40 (n=3) vs Slc4a11+/+ MCEnC P39 (n=3).
Contributor(s) Zhang W, Aldave A
Citation(s) 32721020
Submission date Dec 26, 2019
Last update date Aug 13, 2020
Contact name Wenlin Zhang
Organization name UCLA, Jules Stein Eye Institute
Street address 200 Stein Plaza, Dserc 3-143
City Los Angeles
State/province CA
ZIP/Postal code 90095
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (12)
GSM4233260 KO-P7-1
GSM4233261 KO-P7-2
GSM4233262 KO-P7-3
BioProject PRJNA597783
SRA SRP238853

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Supplementary file Size Download File type/resource
GSE142635_MCEnC_KOvsWT_early.txt.gz 892.6 Kb (ftp)(http) TXT
GSE142635_MCEnC_KOvsWT_late.txt.gz 891.3 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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