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| Status |
Public on Jan 08, 2009 |
| Title |
Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected transgenic mice overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) with Mycobacterium tuberculosis by aerosol and found increased bacterial loads in the lungs of macIL-10tg mice.
To identify programs of genes regulated by IL-10 and associated with increased mycobacterial replication, genome-wide expression analysis was performed.
Keywords: Effect of infection; effect of genotype; timecourse
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| |
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| Overall design |
Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infection
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| |
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| Contributor(s) |
Lang R, Hölscher C |
| Citation(s) |
19561100 |
| Submission date |
Jan 07, 2009 |
| Last update date |
May 04, 2018 |
| Contact name |
Roland Lang |
| E-mail(s) |
roland.lang@uk-erlangen.de
|
| Organization name |
University Hospital Erlangen
|
| Street address |
Wasserturmstr. 3-5
|
| City |
Erlangen |
| ZIP/Postal code |
91054 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA111319 |
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