|
| Status |
Public on Nov 01, 2020 |
| Title |
Dual Targeting of G9a and DNMT1 for the Treatment of Experimental Cholangiocarcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Cholangiocarcinogenesis involves epigenetic abnormalities of great relevance. Both the histone methyltransferase G9A and the DNA methyltransferase DNMT1 are overexpressed in this tumor. We used microarrays to evaluate the global programme of gene expression in the human CCA cell line EGI-1 treated with CM272. This molecule is an epigenetic inhibitor that simultaneously targets the methyltransferase activities of G9a and DNMT1.
EGI-1 cells treatment with CM272 (200nM) or vehicle (0.01% DMSO) for 48 hours.
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| |
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| Overall design |
4 samples
|
| |
|
| Contributor(s) |
Avila M, Colyn L |
| Citation missing |
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| Submission date |
Jan 23, 2020 |
| Last update date |
Nov 02, 2020 |
| Contact name |
Maite G Fernandez-Barrena |
| E-mail(s) |
magarfer@unav.es
|
| Organization name |
CIMA
|
| Street address |
Pio XII 55
|
| City |
Pamplona |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
|
| Samples (4)
|
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| Relations |
| BioProject |
PRJNA602946 |
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