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Series GSE144858 Query DataSets for GSE144858
Status Public on Nov 18, 2020
Title An epigenome-wide association study of Alzheimer’s disease blood highlights robust DNA hypermethylation in the HOXB6 gene.
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Alzheimer case-control samples originate from the EU funded AddNeuroMed Cohort, which is a large cross-European AD biomarker study relying on human blood as the source of DNA.
 
Overall design Case-control design. Cases are Alzheimer's disease patients, individuals with mild cognitive impairment (MCI), or controls. The individuals with MCI can be further divided into individuals who had MCI at baseline blood extraction but progressed to AD within one year, or MCI individuals who didn't progress to AD within one year (see characteristics: disease status2). The criterion 'age<65.exclusion' indicates whether samples were taken into account after applying the exclusion criterion of individuals who are younger than 65 years of age.
 
Contributor(s) Lunnon K, Roubroeks J
Citation(s) 32745807
Submission date Feb 06, 2020
Last update date Nov 18, 2020
Contact name Katie Lunnon
Organization name University of Exeter
Lab Dementia Genomics
Street address RILD South, Barrack Road
City Exeter
State/province Devon
ZIP/Postal code EX2 5DW
Country United Kingdom
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (300)
GSM4299202 Genomic DNA from blood 1
GSM4299203 Genomic DNA from blood 2
GSM4299204 Genomic DNA from blood 3
Relations
BioProject PRJNA605174

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE144858_Matrix_Signal_Intensities.csv.gz 664.5 Mb (ftp)(http) CSV
GSE144858_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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