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| Status |
Public on Feb 10, 2020 |
| Title |
SCA17 knock-in mice brain transcriptomes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To identify brain region specific proteins that contribute to brain region specific neurodegeneration, RNA sequencing was performed using cerebellum, striatum and prefrontal cortex tissues from 3-month-old SCA17 knock-in (KI) mice and wild-type (WT) littermates. We find 245 cerebellar specifically dysregulated genes (110 up-regulated genes and 145 down-regulated genes), 133 striatum specifically dysregulated genes (45 up-regulated genes and 88 down-regulated genes) and 17 prefrontal cortex specifically dysregulated genes (4 up-regulated genes and 13 down-regulated genes). Combined with other evidences, we demonstrate that cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of Spinocerebellar ataxias type 17
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| |
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| Overall design |
To compare RNA level of cerebellum, striatum and prefrontal cortex from 3-month old WT and KI mice of SCA-17 by RNA sequencing, each group consists three mice.
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| Contributor(s) |
Liu Q, Pan Y, Li S, Li X, Tharp G |
| Citation(s) |
32107387 |
| Submission date |
Feb 10, 2020 |
| Last update date |
Mar 09, 2020 |
| Contact name |
Gregory K Tharp |
| E-mail(s) |
gktharp@emory.edu
|
| Phone |
404-727-7797
|
| Organization name |
Yerkes National Primate Research Center
|
| Department |
Developmental and Cognitive Neuroscience
|
| Lab |
Genomics Core
|
| Street address |
954 Gatewood Dr
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30329-4208 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA605839 |
| SRA |
SRP248035 |
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