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Series GSE145147 Query DataSets for GSE145147
Status Public on Feb 13, 2020
Title A role of the CTCF binding site at enhancer Ea in Tcra rearrangement
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Other
Summary We found that the CTCF binding site (named as EACBE) at the enhancer Eα of Tcra is essential for normal Tcra rearrangement.The EACBE deletion impaired the TAD structure of the 3’ region of the Tcra/d locus and the interactions between the proximal Vα genes and the Jα genes without changing the accessibility of the Jα array.
 
Overall design Histone modification, repertoire and chromatin conformation profiles of 4-8 weeks old wild type (WT) and EACBE-/- mice were generated by deep sequencing, in duplicate, using Illumina Hiseq.
 
Contributor(s) Zhao H, Li Z
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Feb 12, 2020
Last update date Feb 15, 2020
Contact name Hao bingtao
E-mail(s) haobingtao@gmail.com
Phone 18578669173
Organization name Southern Medical University
Street address ShataiNan Road, Baiyun District, Guangzhou, Guangdong Province
City Guangzhou
ZIP/Postal code haobingtao@gmail.com
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (40)
GSM4307197 DP-Rag2ko-CBEko-H3K4me3-rep1
GSM4307198 DP-Rag2ko-CBEko-H3K4me3-rep2
GSM4307199 DP-Rag2ko-CBEwt-H3K4me3-rep1
Relations
BioProject PRJNA606188
SRA SRP248393

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145147_RAW.tar 2.5 Gb (http)(custom) TAR (of BED, BEDGRAPH, BW, CSV, HIC)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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