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Status |
Public on Dec 28, 2009 |
Title |
Effect of PPARγ inhibition on pulmonary endothelial cell gene expression: Gene profiling in pulmonary hypertension |
Platform organism |
Bos taurus |
Sample organisms |
Bos taurus; Ovis aries |
Experiment type |
Expression profiling by array
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Summary |
The loss of PPARγ is found to be associated with the development of pulmonary hypertension (PH). We hypothesize that PPARγ inhibition induced gene expression changes may underscore the endothelial dysfunction in the disease process. We utilized microarray analysis to determine gene expression changes in PPARγ inhibited ovine PAECs.
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Overall design |
Ovine PAECs were treated with vehicle (DMSO) or GW9662 (5μM) for 24hrs, and total RNA was extracted for microarray analysis.
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Contributor(s) |
Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Kumar S, Eglaish M, Oishi P, Görlach A, Fratz S, Hess J, Catravas J, Verin J, Fineman J, She J, Black SM |
Citation missing |
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Submission date |
Jan 23, 2009 |
Last update date |
Mar 06, 2020 |
Contact name |
Jing Tian |
E-mail(s) |
jtian@mcg.edu
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Phone |
706-721-0074
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Organization name |
Medical College of Georgia
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Department |
Vascular Biology Center
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Lab |
Lab of Stephen M. Black
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Street address |
1459 Laney Walker BLVD
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City |
Augusta |
State/province |
GA |
ZIP/Postal code |
30912 |
Country |
USA |
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Platforms (1) |
GPL2112 |
[Bovine] Affymetrix Bovine Genome Array |
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Samples (15)
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Relations |
BioProject |
PRJNA111639 |