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| Status |
Public on May 10, 2011 |
| Title |
Expression data from adult rat subventricular zone cells |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Transforming growth factor (TGF)-ß1 is a multifunctional cytokine regulating a number of physiological and patho-physiological processes in the adult brain. Its expression is elevated during neurodegeneration, which is associated with reduced levels of neurogenesis. We have postulated that TGF-ß1 might be one of the crucial factors involved in limiting neurogenesis in the diseased brain.
We used microarrays to detail the gene expression profile after TGFbeta-1 treatment and identified distinct classes of up- and downregulated genes.
Keywords: control versus TGFbeta1 treated group
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| Overall design |
Adult rat subventricular zone cells were cultured for 7 days under proliferation conditions. Control cells were exposed to HCl/BSA whereas TGFbeta-1 treated cells received 10 ng/ml TGFbeta-1 dissolved in HCl/BSA 3 times per week. RNA was extracted followed by hybridization on Affymetrix microarrays.
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| Contributor(s) |
Lehner B, Aigner L |
| Citation(s) |
24779367 |
| Submission date |
Jan 25, 2009 |
| Last update date |
Aug 01, 2019 |
| Contact name |
Dietrich Trümbach |
| E-mail(s) |
dietrich.truembach@helmholtz-muenchen.de
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| Organization name |
German Research Center for Environmental Health
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| Department |
Institute for Developmental Genetics
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| Street address |
Ingolstädter Landstraße 1
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| City |
München-Neuherberg |
| ZIP/Postal code |
85764 |
| Country |
Germany |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA111743 |
