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Series GSE145775 Query DataSets for GSE145775
Status Public on Feb 20, 2021
Title Setdb1 is required for formation of pancreatic ductal adenocarcinoma by inhibiting p53-mediated apoptosis in mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Setdb1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes tumorigenesis in various cancers. However, the functional role of Setdb1 in pancreatic ductal adenocarcinoma formation is still unknown. To reveal the role of Setdb1 in murine pancreata, we have employed whole genome microarray expression profiling of Ptf1aCre; KrasLSL-G12D; Setdb1flox/flox pancreata. We found that apoptotic signaling pathway is upregulated in Setdb1-deficient pancreata.
 
Overall design We used the isolated acinar cells of Ptf1aCre; KrasLSL-G12D; Setdb1flox/flox pancreata as samples and compared to those of Ptf1aCre; KrasLSL-G12D pancreata.
 
Contributor(s) Ogawa S, Fukuda A
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Submission date Feb 23, 2020
Last update date Feb 22, 2021
Contact name Satoshi Ogawa
E-mail(s) sogawa@kuhp.kyoto-u.ac.jp
Organization name Kyoto University Graduate School of Medicine
Lab Satoshi Ogawa
Street address 54 Syogoinkawahara-cho, Sakyo-ku, Kyoto
City Kyoto
State/province Kyoto
ZIP/Postal code 606-8507
Country Japan
 
Platforms (1)
GPL21163 Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version]
Samples (6)
GSM4332635 KCS1
GSM4332636 KC1
GSM4332637 KC2
Relations
BioProject PRJNA608196

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145775_RAW.tar 30.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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