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Status |
Public on Feb 20, 2021 |
Title |
Setdb1 is required for formation of pancreatic ductal adenocarcinoma by inhibiting p53-mediated apoptosis in mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Setdb1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes tumorigenesis in various cancers. However, the functional role of Setdb1 in pancreatic ductal adenocarcinoma formation is still unknown. To reveal the role of Setdb1 in murine pancreata, we have employed whole genome microarray expression profiling of Ptf1aCre; KrasLSL-G12D; Setdb1flox/flox pancreata. We found that apoptotic signaling pathway is upregulated in Setdb1-deficient pancreata.
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Overall design |
We used the isolated acinar cells of Ptf1aCre; KrasLSL-G12D; Setdb1flox/flox pancreata as samples and compared to those of Ptf1aCre; KrasLSL-G12D pancreata.
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Contributor(s) |
Ogawa S, Fukuda A |
Citation missing |
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Submission date |
Feb 23, 2020 |
Last update date |
Feb 22, 2021 |
Contact name |
Satoshi Ogawa |
E-mail(s) |
sogawa@kuhp.kyoto-u.ac.jp
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Organization name |
Kyoto University Graduate School of Medicine
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Lab |
Satoshi Ogawa
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Street address |
54 Syogoinkawahara-cho, Sakyo-ku, Kyoto
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City |
Kyoto |
State/province |
Kyoto |
ZIP/Postal code |
606-8507 |
Country |
Japan |
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Platforms (1) |
GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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Samples (6)
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Relations |
BioProject |
PRJNA608196 |