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Series GSE148588 Query DataSets for GSE148588
Status Public on Dec 21, 2020
Title RNA-Seq of vocal folds of rabbits exposed to a low relative humidity environment
Organism Oryctolagus cuniculus
Experiment type Expression profiling by high throughput sequencing
Summary The purpose of this study is to investigate if acute mucosal dehydration as a funcition of low relative humidty environment impacts the vocal folds at the mRNA level. Rabbits were used as animal model to enable a systematic and rigorous assessment of the pathobiology of vocal fold hydration since they can be manipulated in a physiologically realistic manner. We anticipate that the results of this study will help to elucidate the effects of altered mucosal hydration state in response to low ambient humidity on vocal fold epithelium, lamina propria and muscle tissue at the transcriptome level. Together with cellular, structural, and functional techniques that are part of this project, we expect to provide validated scientific recommendations on the adverse effects of mucosal dehydration and the therapeutic benefits of hydration.
Overall design The transcriptome of vocal folds of rabbits that were exposed to low relative humidity (n=6) were compared to those from rabbits held at a standard ambient humidity (n=6).
Contributor(s) Bailey TW, Sivasankar P, Cox A, Jyothi T, Shaojun X
Citation(s) 33308144
Submission date Apr 13, 2020
Last update date Dec 21, 2020
Contact name Shaojun Xie
Organization name Purdue University
Street address 155 South Grant Street
State/province Indiana
ZIP/Postal code 47906
Country USA
Platforms (1)
GPL26786 Illumina NovaSeq 6000 (Oryctolagus cuniculus)
Samples (12)
GSM4474566 Larynx, CH34
GSM4474567 Larynx, CH35
GSM4474568 Larynx, CH36
BioProject PRJNA625084
SRA SRP256297

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Supplementary file Size Download File type/resource
GSE148588_count_matrix.tsv.gz 440.7 Kb (ftp)(http) TSV
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