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| Status |
Public on Feb 20, 2009 |
| Title |
Type I Interferon: Potential Therapeutic Target for Psoriasis? |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occurred at the same disease sites.
Keywords: Affymetrix Human Genome U133 Plus 2.0 array
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| Overall design |
A total of 82 Affymetrix HGU133 Plus arrays were run on 54 total subjects. This includes: skin biopsy samples from 21 normal healthy donors (Normal-1 to Normal-21), 56 skin biopsy samples from 28 psoriasis patients who had match lesional and uninvolved (non-lesional) tissue (NS-1/LS-1 to NS-9/LS-9, NS-11/LS-11 to NS-14/LS-14, and NS-16/LS-16 to NS-30/LS-30), and 5 samples from psoriasis patients that only provided lesional skin biopsies (LS-10, LS-15, and LS-31 to LS-33).
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| Contributor(s) |
Higgs BW |
| Citation(s) |
18648529 |
| Submission date |
Feb 19, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Brandon W Higgs |
| E-mail(s) |
higgsb@medimmune.com
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| Phone |
3013985014
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| Organization name |
MedImmune, LLC
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| Department |
Translational Science
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| Street address |
One MedImmune Way
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| City |
Gaithersburg |
| State/province |
MD |
| ZIP/Postal code |
20878 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (82)
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| GSM372289 |
Normal Skin, Normal-4 |
| GSM372290 |
Normal Skin, Normal-5 |
| GSM372291 |
Normal Skin, Normal-6 |
| GSM372292 |
Normal Skin, Normal-7 |
| GSM372293 |
Normal Skin, Normal-8 |
| GSM372294 |
Normal Skin, Normal-9 |
| GSM372295 |
Normal Skin, Normal-10 |
| GSM372296 |
Normal Skin, Normal-11 |
| GSM372297 |
Normal Skin, Normal-12 |
| GSM372298 |
Normal Skin, Normal-13 |
| GSM372299 |
Normal Skin, Normal-14 |
| GSM372300 |
Normal Skin, Normal-15 |
| GSM372301 |
Normal Skin, Normal-16 |
| GSM372302 |
Normal Skin, Normal-17 |
| GSM372303 |
Normal Skin, Normal-18 |
| GSM372304 |
Normal Skin, Normal-19 |
| GSM372305 |
Normal Skin, Normal-20 |
| GSM372306 |
Normal Skin, Normal-21 |
| GSM372307 |
Uninvolved Skin, NS-1 |
| GSM372308 |
Lesion Skin, LS-1 |
| GSM372309 |
Uninvolved Skin, NS-2 |
| GSM372310 |
Lesion Skin, LS-2 |
| GSM372311 |
Uninvolved Skin, NS-3 |
| GSM372312 |
Lesion Skin, LS-3 |
| GSM372313 |
Uninvolved Skin, NS-4 |
| GSM372314 |
Lesion Skin, LS-4 |
| GSM372315 |
Uninvolved Skin, NS-5 |
| GSM372316 |
Lesion Skin, LS-5 |
| GSM372317 |
Uninvolved Skin, NS-6 |
| GSM372318 |
Lesion Skin, LS-6 |
| GSM372319 |
Uninvolved Skin, NS-7 |
| GSM372320 |
Lesion Skin, LS-7 |
| GSM372321 |
Uninvolved Skin, NS-8 |
| GSM372322 |
Lesion Skin, LS-8 |
| GSM372323 |
Uninvolved Skin, NS-9 |
| GSM372324 |
Lesion Skin, LS-9 |
| GSM372325 |
Lesion Skin, LS-10 |
| GSM372326 |
Uninvolved Skin, NS-11 |
| GSM372327 |
Lesion Skin, LS-11 |
| GSM372328 |
Uninvolved Skin, NS-12 |
| GSM372329 |
Lesion Skin, LS-12 |
| GSM372330 |
Uninvolved Skin, NS-13 |
| GSM372331 |
Lesion Skin, LS-13 |
| GSM372332 |
Uninvolved Skin, NS-14 |
| GSM372333 |
Lesion Skin, LS-14 |
| GSM372334 |
Lesion Skin, LS-15 |
| GSM372335 |
Uninvolved Skin, NS-16 |
| GSM372336 |
Lesion Skin, LS-16 |
| GSM372337 |
Uninvolved Skin, NS-17 |
| GSM372338 |
Lesion Skin, LS-17 |
| GSM372339 |
Uninvolved Skin, NS-18 |
| GSM372340 |
Lesion Skin, LS-18 |
| GSM372341 |
Uninvolved Skin, NS-19 |
| GSM372342 |
Lesion Skin, LS-19 |
| GSM372343 |
Uninvolved Skin, NS-20 |
| GSM372344 |
Lesion Skin, LS-20 |
| GSM372345 |
Uninvolved Skin, NS-21 |
| GSM372346 |
Lesion Skin, LS-21 |
| GSM372347 |
Uninvolved Skin, NS-22 |
| GSM372348 |
Lesion Skin, LS-22 |
| GSM372349 |
Uninvolved Skin, NS-23 |
| GSM372350 |
Lesion Skin, LS-23 |
| GSM372351 |
Uninvolved Skin, NS-24 |
| GSM372352 |
Lesion Skin, LS-24 |
| GSM372353 |
Uninvolved Skin, NS-25 |
| GSM372354 |
Lesion Skin, LS-25 |
| GSM372355 |
Uninvolved Skin, NS-26 |
| GSM372356 |
Lesion Skin, LS-26 |
| GSM372357 |
Uninvolved Skin, NS-27 |
| GSM372358 |
Lesion Skin, LS-27 |
| GSM372359 |
Uninvolved Skin, NS-28 |
| GSM372360 |
Lesion Skin, LS-28 |
| GSM372361 |
Uninvolved Skin, NS-29 |
| GSM372362 |
Lesion Skin, LS-29 |
| GSM372363 |
Uninvolved Skin, NS-30 |
| GSM372364 |
Lesion Skin, LS-30 |
| GSM372365 |
Lesion Skin, LS-31 |
| GSM372366 |
Lesion Skin, LS-32 |
| GSM372367 |
Lesion Skin, LS-33 |
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| Relations |
| BioProject |
PRJNA112007 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE14905_RAW.tar |
374.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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