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| Status |
Public on Apr 25, 2020 |
| Title |
RV infections in asthmatics increase ACE2 expression and stimulate cytokine pathways implicated in COVID19 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We present evidence that (1) viral respiratory infections are potential mechanisms of ACE2 overexpression in patients with asthma and (2) ACE activation regulates multiple cytokine anti-viral responses that could explain a mechanism for cytokine surge and associated tissue damage. These results suggest that the recent finding of severe COVID-19 in asthma patients with recent exacerbations may be attributable to synergistic biomolecular interactions with viral co-infections.
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| Overall design |
In a paired design experiments across discovery and validation cohorts of in asthmatic patients the biological replicates treated with RVA and RVC were compared to non-treated ones.
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| Contributor(s) |
Chang EH, Willis AL, Pouladi N, Li J, Lussier YA |
| Citation(s) |
32649217 |
| Submission date |
Apr 24, 2020 |
| Last update date |
Jul 26, 2020 |
| Contact name |
Eugene H Chang |
| E-mail(s) |
echang@email.arizona.edu
|
| Phone |
(520) 626-6673
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| Organization name |
The University of Arizona
|
| Department |
Department of Otolaryngology
|
| Lab |
Eugene Lab
|
| Street address |
1501 N. Campbell Avenue
|
| City |
Tucson |
| State/province |
AZ |
| ZIP/Postal code |
85724 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (90)
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| Relations |
| BioProject |
PRJNA627860 |
| SRA |
SRP258285 |
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