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| Status |
Public on Apr 27, 2020 |
| Title |
Transcriptome profiling of rat brain samples in two age groups in responding to intracerebral hemorrhage |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Aging-induced decline of endogenous neuroprotection has been shown to aggravate intracerebral hemorrhage (ICH)-induced acute brain injury, however, the underlying mechanisms in brain are still little known. In this study, we applied a rat ICH model to study the transcriptional responses in the early and late aging (13-month and 22-month old) rats that show substantial differences in brain damage and recovery. Transcriptome analysis (RNA-seq) reveals that brain expression of neuroinflammation genes is similarly and selectively upregulated in ICH, which includes genes in the cellular response to interferon gamma function. We show that the anti-IFN-γ treatment effectively reduces ICH-induced acute brain injury.
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| Overall design |
Rats from two age groups, including 13-month and 22-month, were selected to perform experiments. Left brains of rats were treated with intracerebral hemorrhage, while right brains were as control. Three biological replicates were used to perform RNA-seq experiments. A total of 12 RNA-seq samples were obtained.
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| Contributor(s) |
Zhang Y, Yang Q |
| Citation(s) |
33071720 |
| Submission date |
Apr 24, 2020 |
| Last update date |
Oct 27, 2020 |
| Contact name |
dong chen |
| Organization name |
ablife
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| Street address |
GaoXin 2nd Road
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| City |
wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430064 |
| Country |
China |
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| Platforms (1) |
| GPL24688 |
HiSeq X Ten (Rattus norvegicus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA627944 |
| SRA |
SRP258355 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE149317_expressed_gene_FPKM.txt.gz |
1.2 Mb |
(ftp)(http) |
TXT |
| GSE149317_expressed_gene_reads.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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