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| Status |
Public on Apr 30, 2020 |
| Title |
A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In this study, we investigated differential genetic expression patterns among TMSCs with different cultivation times and passage numbers. Transcriptomic approaches were used to further identify novel candidate biomarkers of culture-aged, senescent TMSCs. These analyses have led us to propose that genes associated with ECM are differentially altered with aging of TMSCs, and some of these molecules could be used as potential indicators for identifying stem cells with senescence.
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| Overall design |
Total 4 Samples, 2 Sample Groups, 1 Comparisons. (test vs. control) (Control TMSC vs. Culture-aged TMSC)
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| |
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| Contributor(s) |
Park YS, Choi DH |
| Citation(s) |
32807231, 35910534 |
| Submission date |
Apr 29, 2020 |
| Last update date |
Aug 03, 2022 |
| Contact name |
Da Hyeon Choi |
| E-mail(s) |
dahyun6682@gmail.com
|
| Phone |
+82-10-7127-2726
|
| Organization name |
Chungbuk National University
|
| Street address |
Major in Microbiology, School of Biological Sciences, College of Natural Sciences
|
| City |
Cheongju |
| ZIP/Postal code |
28644 |
| Country |
South Korea |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA629315 |
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