|
| Status |
Public on Oct 01, 2020 |
| Title |
Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability (END-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
Our study uncovers a distinct biomarker for MSI that underlies the synthetic lethal dependence on WRN, thereby supporting the development of WRN-based therapeutics
|
| |
|
| Overall design |
ENDseq was performed under different experimental condition in MSI and MSS cells to uncovers sites of recurrent DNA damage genome-wide
|
| |
|
| Contributor(s) |
Van Wietmarschen N, Sridharan S, Nussenzweig A |
| Citation(s) |
32999459 |
| Submission date |
May 01, 2020 |
| Last update date |
Feb 17, 2021 |
| Contact name |
Andre Nussenzweig |
| E-mail(s) |
nussenza@mail.nih.gov
|
| Organization name |
National Institutes of Health
|
| Department |
National Cancer Institute
|
| Lab |
Laboratory of Genome Integrity
|
| Street address |
9000 Rockville Pike, Building 37
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (34)
|
|
| This SubSeries is part of SuperSeries: |
| GSE149709 |
Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability |
|
| Relations |
| BioProject |
PRJNA629785 |
| SRA |
SRP259921 |
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