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Series GSE150417 Query DataSets for GSE150417
Status Public on May 21, 2021
Title Genome-wide DNA Methylation Analysis along the Progression of Gastric Marginal Zone B-cell Lymphoma of MALT Type
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Extranodal marginal zone B-cell lymphoma (MZBL) of the mucosa-associated lymphoid tissue (MALT) is an indolent lymphoma mostly affecting the gastrointestinal tract. In the stomach, MZBL of MALT initially has small cell morphology (SC-MZBL) and arises in the background of Helicobacter pylori induced gastritis. Clonal malignant progression to large cell morphology (LC-MZBL) is observed. During this progression an intermediate stage consisting of both the small cell and large cell morphology is present, called "composite lymphoma". To gain insight into the DNA methylation changes associated with progression of gastric MZBL of MALT, we performed genome-wide DNA methylation profiling using the Illumina Infinium MethylationEPIC BeadChip array for 30 microdissected samples of gastric MZBL of MALT.
 
Overall design Bisulphite converted DNA from 30 gastric MZBL of MALT samples were amplified, fragmented and hybridised to Illumina Infinium MethylationEPIC BeadChip.
 
Contributor(s) Dugge R, Wagener R, Mӧller P, Barth TF
Citation(s) 33590882
Submission date May 12, 2020
Last update date Aug 30, 2021
Contact name Thomas FE Barth
E-mail(s) Thomas.Barth@uniklinik-ulm.de
Organization name Ulm University
Department Pathology
Street address Albert-Einstein-Allee 11
City Ulm
State/province Select...
ZIP/Postal code 89081
Country Germany
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (30)
GSM4550144 SC-1: small cell MALT lymphoma 1
GSM4550145 SC-2: small cell MALT lymphoma 2
GSM4550146 SC-3: small cell MALT lymphoma 3
Relations
BioProject PRJNA632008

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150417_Matrix_AvgBeta.txt.gz 114.7 Mb (ftp)(http) TXT
GSE150417_Matrix_signal_intensity.txt.gz 226.2 Mb (ftp)(http) TXT
GSE150417_RAW.tar 583.4 Mb (http)(custom) TAR (of IDAT)
Processed data are available on Series record
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