|
| Status |
Public on Nov 26, 2020 |
| Title |
Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Disease tolerance is an important alternative strategy for rapidly acquired immunity to malaria. We show that tolerance is induced by a single malaria episode - in the absence of parasite clearance.
Inflammatory spleen monocytes from C57Bl6/J mice with memory of malaria infection dramatically change their transcriptional response to a second infection; instead of driving emergency inflammation they promote stress and tissue tolerance (RNAseq data available in GEO series GSE150047).
This unique functional profile is not underpinned by alterations in the epigenetic landscape of inflammatory monocytes before their release from the bone marrow (ChIPseq data available in GEO series GSE150478) - tolerance is therefore imprinted within the spleen (microarray data available in GEO series GSE149894).
Hosts thus acquire long-lasting mechanisms that control inflammation (reducing collateral tissue damage) and learn to actively promote stress tolerance (protecting tissues against toxic products and processes) after one malaria episode.
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| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
33752799 |
| Submission date |
May 13, 2020 |
| Last update date |
Mar 29, 2021 |
| Contact name |
Alasdair Ivens |
| E-mail(s) |
al.ivens@ed.ac.uk
|
| Phone |
44 131 6513605
|
| Organization name |
Centre for Immunity, Infection and Evolution
|
| Street address |
Kings Buildings
|
| City |
Edinburgh |
| ZIP/Postal code |
EH9 3FL |
| Country |
United Kingdom |
| |
|
| Platforms (4)
|
| GPL20258 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CDF version] |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
| GPL21626 |
NextSeq 550 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (91)
|
|
| This SuperSeries is composed of the following SubSeries: |
| GSE149894 |
Tissue printing: splenic red pulp macrophages of once-malaria infected mice are transcriptionally identical to prenatally seeded red pulp macrophages from uninfected mice. |
| GSE150047 |
A single malaria episode induces mechanisms that minimise inflammation and promote tolerance in spleen inflammatory monocytes. |
| GSE150478 |
Bone marrow monocytes from once-malaria infected mice have no epigenetic memory of the infection. |
|
| Relations |
| BioProject |
PRJNA632548 |
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