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| Status |
Public on May 14, 2020 |
| Title |
7-Hydroxycoumarin attenuates colistin-induced kidney injury in mice through the inhibition of HDAC1 and the activation of Nrf2 signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RNA sequencing of kidney tissues was performed to investigate the mechanism of 7-Hydroxycoumarin attenuates colistin-induced kidney injury in mice
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| Overall design |
This study aimed to investigates the renoprotective effect of 7-Hydroxycoumarin (7-HC) against colisitn-induced kidney injury. Mice were randomly divided into four groups: saline solution (con group); 7-HC administered at 50 mg/kg of body weight/day (7-HC group); colistin at 15 mg/kg/day (col group); colistin at 15 mg/kg/day plus 7-HC at 50mg/kg/day (col+7-HC group). All mice were treated for 7 consecutive days, kidney tissued were collected and used to RNA sequencing.
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| Contributor(s) |
Wang J |
| Citation(s) |
32848758 |
| Submission date |
May 13, 2020 |
| Last update date |
Aug 31, 2020 |
| Contact name |
Jian Wang |
| E-mail(s) |
wangjian8@genomics.cn
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| Organization name |
Northeast Agricultural University
|
| Street address |
600 Changjiang Road
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| City |
Harbin |
| ZIP/Postal code |
150030 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA632626 |
| SRA |
SRP261504 |
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