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| Status |
Public on Jul 20, 2020 |
| Title |
Highly accurate Skin-Specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging [DS3] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
In the present study, we developed a highly accurate Skin-Specific DNAm age predictor, using DNAm data obtained from 508 human skin samples. Based on the analysis of 2,266 CpG sites, we accurately calculated the DNAm age of cultured skin cells, and human skin biopsies. Age estimation was sensitive to the biological age of the donor, cell passage, skin disease status, as well as treatment with senotherapeutic drugs.
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| Overall design |
Analyze the difference in methylation profile on human dermal fibroblasts isolated from a young donor (29 years) and a elderly donor (84 years). Sample 1: human dermal fibrblasts from a 29 years old donor, in triplicate Sample 2: human dermal fibrblasts from a 84 years old donor, in triplicate
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| Contributor(s) |
Boroni M, Zonari A |
| Citation(s) |
32660606 |
| Submission date |
Jun 01, 2020 |
| Last update date |
Jul 20, 2020 |
| Contact name |
Mariana Boroni |
| E-mail(s) |
lbbc.inca@gmail.com, marianaboroni@gmail.com
|
| Organization name |
Instituto Nacional de Câncer
|
| Lab |
Laboratório de Bioinformática e Biologia Computacional
|
| Street address |
Rua André Cavalcanti 37
|
| City |
Rio de Janeiro |
| State/province |
RJ |
| ZIP/Postal code |
20231-050 |
| Country |
Brazil |
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| Platforms (1) |
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| Samples (6)
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| GSM4586466 |
human_dermal_firboblast_29y_rep1 [201492560033_R01C01] |
| GSM4586467 |
human_dermal_firboblast_29y_rep2 [201492560033_R02C01] |
| GSM4586468 |
human_dermal_firboblast_29y_rep3 [201492560033_R03C01] |
| GSM4586469 |
human_dermal_firboblast_84y_rep1 [201492560033_R04C01] |
| GSM4586470 |
human_dermal_firboblast_84y_rep2 [201492560033_R05C01] |
| GSM4586471 |
human_dermal_firboblast_84y_rep3 [201492560033_R06C01] |
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| This SubSeries is part of SuperSeries: |
| GSE151617 |
Highly accurate Skin-Specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging |
|
| Relations |
| BioProject |
PRJNA636518 |
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