NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE15184 Query DataSets for GSE15184
Status Public on Jun 04, 2010
Title Global colorectal cancer gene expression in rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary The rat models of colorectal cancer (CRC), such as the azoxymethane (AOM) cancer-inducing model, are important tools for researching cancer initiation pathways. However, there is limited understanding of the expression pathways of underlying normal rat colonic epithelium and how this relates to human colonic epithelium. The aim of this study was to study the acute effects of AOM on the gene and pathway expression of the rat's colonic epithelium, whilst contrasting the background normal global expression patterns along the length of the rat as compared to the normal human colonic epithelium.
 
Overall design The study used microarrays to investigate global gene expression of the colonic epithelium from proximal and distal sections of AOM- and saline (normal)-treated Sprague Dawley rats. Rat gene and pathway expression patterns were then compared in-silico with human microarray data (see GSE9254 for files) from normal tissue samples originating from proximal and distal regions of the colon.
 
Contributor(s) Kerr CA, Hines BM, Shaw J, Dunne R, Bragg LM, Clarke J, Wilson WJ, Lockett T, Head R
Citation(s) 23343511
Submission date Mar 11, 2009
Last update date Jul 31, 2017
Contact name Caroline Audrey Kerr
E-mail(s) Caroline.Kerr@csiro.au
Phone +61 2 94905063
Fax +61 2 94905010
Organization name CSIRO
Department Moelcular health Technologies
Lab North Ryde
Street address 11 Julius Ave North Ryde
City Sydney
State/province NSW
ZIP/Postal code 2113
Country Australia
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (38)
GSM379003 distal-colon-AOM-rat-1
GSM379004 proximal-colon-AOM-rat-1
GSM379005 distal-colon-AOM-rat-5
Relations
BioProject PRJNA116395

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15184_RAW.tar 108.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap